The Zhang Group

Group News

Congrats Yang Shen! Our collaborative work with Prof. Xingwang Zhang and Prof. Shengying Li at Shandong University and Prof. Bingju Wang at Xiamen University "Deciphering the Thiolactonization Mechanism in Thiolactomycin Biosynthesis" was accepted by [J. Am. Chem. Soc] as an article. (June 19, 2025) Congrats Peng Chen and Yushan Qin! Our collaborative work with Prof. Zhongjian Xie and Prof. Defa Li at Shenzhen Children's Hospital & Affiliated Shenzhen Children's Hospital of Shantou University Medical College "Developing Dual-State Emission Berberine Derivatives as Theranostic Agents by Reducing Nonradiative Transition Pathways" was accepted by [J. Med. Chem.] as an article. (May 25, 2025) Congrats Hong-Xiu Xiao and Haoxiang Wei! Our collaborative work with Prof.Xian-Wen Yang at Third Institute of Oceanography, Ministry of Natural Resources and Prof. Ping Wang at Shanghai University of Traditional Chinese Medicine "Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB" was accepted by [J. Med. Chem.] as an article. (Apr. 19, 2024) Congrats Yujie Niu, Minggui Lin, Hao Cui, and Yang Shen! Our paper "Synthetic Studies toward Pseudolaric Acids: Radical Cyclization to Form Bridged Scaffold" was accepted by [CJC] as a concise report. (Mar. 19, 2024) Congrats Pengfei Fu, Tao Liu, and Yang Shen! Our paper "Divergent Total Syntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization" was accepted by [JACS] as an article. (Aug. 10, 2023) Congrats Hao Cui and Yang Shen! Our account "Synthesis of Clionastatins A and B through Enhancement of Chlorination and Oxidation Levels of Testosterone" was accepted by [CJC]. (Aug. 11, 2022) Congrats Hao Cui and Yang Shen! Our work "Two-Stage Syntheses of Clionastatins A and B" was accepted by [JACS]. (May 16, 2022) Congrats Renzhi Chen, Dongsheng Qiu and Xin Lei! Our work "Total Synthesis and Assignment of the Absolute Configuration of (+)-Omphalic Acid" was accepted by [Org Lett]. (Aug. 16, 2021) Congrats Renzhi Chen, Feng Zhang, and Yuhui Hua! Our work "Total Synthesis of Stemarene and Betaerene Diterpenoids: Divergent Ring-Formation Strategy and Late-Stage C−H Functionalization" was accepted by [CCS Chem]. (Mar. 28, 2021) Congrats Yang Shen, Linbin Li, and Xiaoxia Xiao! Our work "Site-Specific Photochemical Desaturation Enables Divergent Syntheses of Illicium Sesquiterpenes" was accepted by [JACS]. (Feb. 18, 2021) Congrats Xunjin Jiang, Zhixiong Zeng, and Yuhui Hua! Our work "Merging C–H Vinylation with Switchable 6π-Electrocyclizations for Divergent Heterocycle Synthesis" was accepted by [JACS]. (Aug. 12, 2020) Congrats Xunjin Jiang! Our collaborative work with Prof. Hu of XMU Medical School "Structure-Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as RXRα Activator to Inhibit Colon Cancer" was accepted by [J. Med. Chem.]. (May. 12, 2020) Congrats Renzhi Chen, Yang Shen, and Sihan Yang! Our Minireview "Conformational Design Principles in Total Synthesis" was accepted by [Angew. Chem. Int. Ed.]. (Apr. 16, 2020) Congrats Minggui Lin, Hao Cui! Our Communication "Domino enyne metathesis en route to skeletally diverse, privileged scaffolds: synthesis of the tricyclic core of pseudolaric acid F" was accepted by [Org. Chem. Front.]. (Jun. 16, 2019) Congrats Zhixiong Zeng, Yifan Zhao! Our Communication "Divergent total syntheses of five illudalane sesquiterpenes and assignment of the absolute configuration" was accepted by [Chem. Commun.]. (Mar. 15, 2019) Congrats Renzhi Chen, Linbin Li, Na Lin, Rong Zhou, and Hejun Deng! Our Communication "Asymmetric Total Synthesis of (+)-Majusculoic Acid via a Dimerization–Dedimerization Strategy and Absolute Configuration Assignment" was accepted by [Org. Lett.]. (Feb. 15, 2018) Congrats Zhixiong Zeng, Cheng Chen! Our work "Enantioselective Total Synthesis of Periconiasin A" was accepted by [Org. Chem. Front.]. (Dec. 1, 2017) Congrats Minggui Lin, Zhixiong Zeng, Na Lin, Yang Shen, Bin Tang, Fan Li, and Chen Chen! Our work "Conformational Bias by a Removable Silyl Group: Construction of Bicyclo[n.3.1]alkenes via Ring Closing Metathesis" was accepted by [Chem. Eur. J.]. (Nov. 9, 2017) Congrats Chenguang Liu, Renzhi Chen, Yang Shen, and Zhanhao Liang! Our work "Total Synthesis of Aplydactone via a Conformationally Controlled C-H Functionalization" was accepted by [Angew. Chem.]. (May 3, 2017) Congrats Chenguang Liu, Zhixiong Zeng, Renzhi Chen, Xunjin Jiang, Yinglu Wang! Their work "Total Synthesis of (+)-Fusarisetin A Driven by a One-Pot Four-Reaction Process" was accepted by [Org. Lett.]. (Jan. 27, 2016)

Dr. Yandong Zhang （张延东）
	Professor Department of Chemistry Office: 622 Lu Jiaxi Hall Labs: 621&625 Lu Jiaxi Hall Xiamen, Fujian 361005 Tel: +86-592-2181902 Email: ydzhang@xmu.edu.cn
Education Background: Postdoc, Columbia University, 2008-2010 (With Prof. Samuel J. Danishefsky) Ph.D. Peking University, 2004-2008 (With Prof. Zhen Yang and Prof. Jiahua Chen) B. E. Beijing Institute of Technology, 1994-1998 (With Prof. Yingyan Jiang)
Research Interestes: Total Synthesis of natural products of significant biological activities; chemical biology based on small molecule-protein interaction.