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Publications

042. Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB

Xie, C.-H.+; Xiao, H.-X.+; Song, P.-F.+; Liu, Q.-M.+; Wei, H.; Wu, L.; Zhu, G.-H.; Liu, G.-M.;* Zhang, Y.;* Wang, P.;* Yang, X.-W.*

J. Med. Chem. 2024, 67, 7504–7515

+ These authors contributed equally to this work.

041. Synthetic Studies toward Pseudolaric Acids: Radical Cyclization to Form Bridged Scaffold

Niu, Y.+; Lin, M.+; Cui, H.; Shen, Y.;* Zhang, Y.*

Chin. J. Chem. 2024, 42, 1699–1705.

+ These authors contributed equally to this work.

040. Divergent Total Syntheses of Illicium Sesquiterpenes through Late-Stage Skeletal Reorganization

Fu, P.+; Liu, T.+; Shen, Y.+; Lei, X.; Xiao, T.; Chen, P.; Qiu, D.; Wang, Z.; Zhang, Y.*

J. Am. Chem. Soc. 2023, 145, 18642–18648.

+ These authors contributed equally to this work.

039. Unexpected Pyridinyl Group-Mediated Metal-Free Wacker-Type Oxidation en Route to Pyrido[2,1-a]isoindol-5-ium Salts

Shi, D.; Zeng, T.; Lei, X.; Wu, X.; Li, M.; Zhang, Y.*

Synthesis 2022, 54, 5434–5444.

038. Synthesis of Clionastatins A and B through Enhancement of Chlorination and Oxidation Levels of Testosterone

Cui, H.+; Shen, Y.+; Wang, R.; Wei, H.; Lei, X.; Chen, Y.; Fu, P.; Wang, H.; Bi, R.; Zhang, Y.*

Chin. J. Chem. 2022, 40, 2747–2755.

+ These authors contributed equally to this work.

037. Two-Stage Syntheses of Clionastatins A and B

Cui, H.+; Shen, Y.+; Chen, Y.; Wang, R.; Wei, H.; Fu, P.; Lei, X.; Wang, H.; Bi, R.; Zhang, Y.*

J. Am. Chem. Soc. 2022, 144, 8938–8944.

+ These authors contributed equally to this work.

036. Total Synthesis of Stemarene and Betaerene Diterpenoids: Divergent Ring-Formation Strategy and Late-Stage C−H Functionalization

Chen, R.+; Zhang, F.+; Hua, Y.+; Shi, D.; Lei, X.; Xiao, H.; Wang, Y.; Zhang, Y.*

CCS Chem. 2022, 4, 987–995.

+ These authors contributed equally to this work.

035. Total Synthesis and Assignment of the Absolute Configuration of (+)-Omphalic Acid

Chen, R.; Qiu, D.; Lei, X.; Niu, Y.; Hua, Y.; Peng, H.; Zeng, T.; Zhang, Y.*

Org. Lett. 2021, 23, 6972–6976.

034. Site-Specific Photochemical Desaturation Enables Divergent Syntheses of Illicium Sesquiterpenes

Shen, Y.+; Li, L.+; Xiao, X.+; Yang, S.; Hua, Y.; Wang, Y.; Zhang, Y.-w.;* Zhang, Y.*

J. Am. Chem. Soc. 2021, 143, 3256–3263.

+ These authors contributed equally to this work.

033. Divergent total syntheses of pseudoberberine and nitidine through C–H vinylation and switchable 6π electrocyclizations

Jiang, X.+; Zeng, Z.+; Shi, D.; Liu, C.; Zhang, Y.*

Tetrahedron Lett. 2021, 66, 152839.

+ These authors contributed equally to this work.

032. Synthetic Studies towards Atkamine

Zhang, F.; Niu, Y.; Hong, D.; Ye, Y.; Hua, Y.; Ding, S.; Zhang, Y.*

Chin. Chem. Lett. 2021, 32, 668–671.

031. Merging C–H Vinylation with Switchable 6π-Electrocyclizations for Divergent Heterocycle Synthesis

Jiang, X.+; Zeng, Z.+; Hua, Y.+; Xu, B.; Shen, Y.; Xiong, J.; Qiu, H.; Wu, Y.; Hu, T.;* Zhang, Y.*

J. Am. Chem. Soc. 2020, 142, 15585–15594.

+ These authors contributed equally to this work.

030. Structure-Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as RXRα Activator to Inhibit Colon Cancer

Xu, B.+; Jiang, X.+; Xiong, J.; Lan, J.; Tian, Y.; Zhong, L.; Wang, X.; Xu, N.; Cao, H.; Zhang, W.; Zhang, H.; Hong, X.; Zhan, Y.-y.;* Zhang, Y.;* Hu, T.*

J. Med. Chem. 2020, 63, 5841–5855.

+ These authors contributed equally to this work.

029. Conformational design principles in total synthesis

Chen, R.; Shen, Y.; Yang, S.; Zhang, Y.*

Angew. Chem. Int. Ed. 2020, 59, 14198–14210.

028. Recent progress in the total synthesis of marine brominated sesquiterpene aplydactone

Chen, R.; Yang, S.; Zhang, Y.*

Org. Biomol. Chem. 2020, 18, 1036–1045.

027. Nesteretal A, A Novel Class of Cage-Like Polyketide from Marine-Derived Actinomycete Nesterenkonia halobia

Xie, C.-L.; Chen, R.; Yang, S.; Xia, J.-M.; Zhang, G.-Y.; Chen, C.-H.; Zhang, Y.; Yang, X.-W.*

Org. Lett. 2019, 21, 8174–8177.

024. Asymmetric Total Synthesis of (+)-Majusculoic Acid via a Dimerization–Dedimerization Strategy and Absolute Configuration Assignment

Chen, R.; Li, L.; Lin, N.; Zhou, R.; Hua, Y.; Deng, H.; Zhang, Y.*

Org. Lett. 2018, 20, 1477–1480.

022. Enantioselective total synthesis of periconiasin A

Zeng, Z.; Chen, C.; Zhang, Y.*

Org. Chem. Front. 2018, 5, 838–840.

021. Conformational Bias by a Removable Silyl Group: Construction of Bicyclo[n.3.1]alkenes by Ring Closing Metathesis

Lin, M.; Cai, P.-J.; Zeng, Z.; Lin, N.; Shen, Y.; Tang, B.; Li, F.; Chen, C.; Yu, Z.-X.;* Zhang, Y.*

Chem. Eur. J. 2018, 24, 2334–2338.

020. Total Synthesis of Aplydactone by a Conformationally Controlled C−H Functionalization

Liu, C.+; Chen, R.+; Shen, Y.; Liang, Z.; Hua, Y.; Zhang, Y.*

+ These authors contributed equally to this work.

Angew. Chem. Int. Ed. 2017, 56, 8187–8190.

018. Synthetic Progress of Jiadifenolide

Li, L.; Shen, Y.; Zhang, Y.*

Chin. J. Org. Chem. 2016, 36, 439–446.

017. Total Synthesis of (+)-Fusarisetin A Driven by a One-Pot Four-Reaction Process

Liu, C.; Zeng, Z.; Chen, R.; Jiang, X.; Wang, Y.; Zhang, Y.*

Org. Lett. 2016, 18, 624–627.

015. Protecting-Group-Free Total Synthesis of (−)-Jiadifenolide: Development of a [4 + 1] Annulation toward Multisubstituted Tetrahydrofurans

Shen, Y.; Li, L.; Pan, Z.; Wang, Y.; Li, J.; Wang, K.; Wang, X.; Zhang, Y.; Hu, T.; Zhang, Y.*

Org. Lett. 2015, 17, 5480–5483.

Top 20 Most Read Article in 2016; highlighted by Synfacts

014. The Cyano Group as a Traceless Activation Group for the Intermolecular [3+2] Cycloaddition of Azomethine Ylides: A Five-Step Synthesis of (±)-Isoretronecanol

Li, J.; Zhao, H.; Jiang, X.; Wang, X.; Hu, H.; Yu, L.; Zhang, Y.*

Angew. Chem. Int. Ed. 2015, 54, 6306–6310.

013. Diastereoselective Total Synthesis of (±)-Schindilactone A, Part 1: Construction of the ABC and FGH Ring Systems and Initial Attempts to Construct the CDEF Ring System

Sun, T.; Ren, W.; Xiao, Q.; Tang, Y.; Zhang, Y.; Li, Y.; ,Meng, F.; Liu, Y.; Zhao, M.; Xu, L.; Chen, J.; Yang, Z.

Chem. Asian J. 2012, 7, 2321–2333.

012. Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol

Chou, T.; Dong, H.; Zhang, X.; Lei, X.; Hartung, J.; Zhang, Y.; Lee, J. H.; Danishefsky, S. J.

PNAS. 2011, 108, 14336–14341.

010. A Straightforward Route to Functionalized trans-Diels−Alder Motifs

Lee, J. H.; Zhang, Y. ; Danishefsky, S. J.

J. Am. Chem. Soc. 2010, 132, 14330–14333.

009. Total Synthesis of (±)-Aplykurodinone-1: Traceless Stereochemical Guidance

Zhang, Y. ; Danishefsky, S. J.

J. Am. Chem. Soc. 2010, 132, 9567–9569.

008. Stereoselective Construction of an Unprecedented 7−8 Fused Ring System in Micrandilactone A by [3,3]-Sigmatropic Rearrangement

Zhang, Y. ; Ren, W.; Lan, Y.; Xiao, Q.; Wang, K.; Xu, J.; Chen, J.; Yang, Z.

Org. Lett., 2008, 10, 665–668.

007. Application of RCM Reaction in the Construction of ABC Ring of Micrandilactone A

Zhang, Y. ; Tang, Y.; Luo, T.; Shen, J.; Chen, J.; Yang, Z.

Org. Lett., 2006, 8, 107–110.

006. Thioureas as Ligands in the Pd-Catalyzed Intramolecular Pauson−Khand Reaction

Tang, Y.; Zhang, Y. ; Dai, M.; Luo, T.; Deng, L.; Chen, J.; Yang, Z.

Org. Lett., 2005, 7, 885–888.

004. Tetramethyl Thiourea/Co2(CO)8-Catalyzed Pauson−Khand Reaction under Balloon Pressure of CO

Tang, Y.; Deng, L.; Zhang, Y. ; Dong, G.; Chen, J.; Yang, Z.

Org. Lett., 2005, 7, 593–595.

003. Total Synthesis of Wedelolactone

Li, C.; Xie, Z.; Zhang, Y. ; Chen, J.; Yang, Z.

J. Org. Chem. 2003, 68, 8500–8504.

002. Synthesis of Asymmetric Propanetriol Analogues

Guo, Y.; Chen, J.; Fu, B.; Wang, N.; Jin, S.; Chen, L.; Zou, F.; Zhang, X.; Zhang, Y.; You, Z.

Chin. Chem. Lett. 2002, 13, 811–813.

001. Total Synthesis of Acyl- and Alkyl- LPA

Chen, J.; Zhang, Y.

Acta Sci. Natur. Uni. Pek. 2003, 39, 151–157.

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College of Chemistry and Chemical Engineering, Xiamen University